Chicago nearly called it quits when co-founder Terry Kath died of a self-inflicted gunshot wound in 1978, but they continued with Donnie Dacus, and later, Peter Cetera at the helm.
Despite losing their iconic drummer Keith Moon in 1978 and rhythm powerhouse John Entwistle in 2002, the Who have continued to play sold out shows around the world.
Aussie rockers AC/DC were able to withstand the loss of raucous frontman Bon Scott with Brian Johnson picking up where he left off.
Lead singer Steve Perry may have gone his separate way, but Journey have continued to tour without him.
Boston's original incarnation lasted only three years. Founding member Tom Scholz has managed to keep them together in some form or another ever since.
They may only call themselves the Dead these days, but who do they think they're fooling?
The Doors released three albums following the death of Jim Morrison.
The Rolling Stones raged on despite losing founding member Brian Jones in 1969. The band would record much of their classic material after his death.
Rather than disappear after the death of lead singer Michael Hutchence, INXS continued with various lead singers. In 2004, they were the subject of a reality show called 'Rock Star: INXS.'
Metallica lost two bassists over the course of their 26 year career.
Axl Rose put together a skeleton crew to release Guns N' Roses' long-awaited album, "Chinese Democracy" in 2008.
The Supremes didn't stop (in the name of love) when Diana Ross left the band. They had several hits with the help of new singer Jean Terrell.
Infamous singer Natalie Maines didn't join the Dixie Chicks until their fourth album.
Pink Floyd lost their psychedelic shaman Syd Barrett in 1968, with guitarist David Gilmour replacing him in the band. Gilmour ultimate became the band leader after Roger Waters left in 1985.
Lynyrd Skynyrd went on a decade-long hiatus after a plane crash that claimed the lives of three band members. They have a new album slated for 2009.
Queen never disbanded after HIV/AIDS claimed the life of lead singer Freddie Mercury. They have most recently toured with former Bad Company lead singer Paul Rodgers on lead vocals.
People can debate Van Halen/Van Hagar all they want, but what about Gary Cherone?
Black Sabbath fired Ozzy Osbourne in 1979, as drugs and alcohol took a toll on the band. He was replaced by Ronnie James Dio. Sabbath's original lineup reunited in 1997.
Genesis have mutated from prog rock legends fronted by Peter Gabriel to soft rock trio fronted by Phil Collins.
The Four Tops have existed in one form or another since 1956.
Depeche Mode lost members who spawned such notable spinoff acts as Yazoo and Erasure, but continued to produce electro hits throughout the '80's and '90's.
10,000 Maniacs may have lost Natalie Merchant but they kept "fiddling around" with their violinist as lead singer.
Some members have come and gone, but Def Leppard just keep on rockin'.
Judas Priest formed in 1969 and has sold over 35 million albums worldwide.
The metal amalgamation known as Anthrax has been headbanging for 25 years with a rotating cast of characters.
Today, Duran Duran has more former members than current ones.
After Red Hot Chili Peppers lost guitarist Hillel Slovak to a heroin overdose in 1988, John Frusciante joined the band. Frusciante struggled with addiction and left the band and was replaced by Dave Navarro. Frusciante has since rejoined the band.
The Pretenders lost two members by the time they released their sophomore album. They're still recording and touring today.